Our Projects

We are an ambitious group of researchers with the goal of developing scientific projects that help to improve the prognosis of cancer patients with brain metastases.

Drug discovery
METPlatform
Are there more effective ways to find drugs working against brain metastasis?
Resistance
Radiation
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Resistance
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?
RENACER
RENACER
It is key to validate our experimental findings in human samples.
New tools for better management
NANOBRIGHT
Some of the strategies to diagnose brain tumors are invasive and treatments are frequently not reaching optimal concentrations in the brain; so, could we use new technology to circumvent these aspects?
Research models
BrMPanel
How many models of brain metastasis are available? Do we have the models we want? Are they accurate enough reproducing the human disease? Is it easy to get access to brain metastasis models so new researchers can address unsolved questions? Can we do anything to share this knowledge?
Research models
Local and systemic therapy
We want to know why current therapies, either local or systemic, do not work well against brain metastasis.
The brain with metastasis
Astrocytes
What is the nature of brain metastasis-associated astrocytes?
The brain with metastasis
Microglia, macrophages
Why are microglia/macrophages linked to all brain disorders, including brain metastasis?
The brain with metastasis
Endothelial cells
Do metastases require the generation of new vessels to thrive?
The brain with metastasis
Neurons
Is it possible to limit the impact of metastasis on brain function?
Prevention
Vascular co-option
Is there any realistic opportunity to develop preventive strategies against metastasis?
Omics
BrMETomic
Can we identify brain metastases subtypes by analyzing large omic datasets?