Publications

Our publications reflect our interests in the fields of Cancer Biology and Neuroscience. This allows us to study brain metastases using a variety of techniques. Here are our most significant contributions to both disciplines.

2024. Brain Metastasis Group publications 

TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.

Cancer Discovery (2024)

First author/s: Priego N et al.
Corresponding author/s: Valiente M

RET overexpression leads to increased brain metastatic competency in luminal breast cancer

JNCI: Journal of the National Cancer Institute (2024)

First Author/s: Jagust P et al.
Corresponding author/s:Young L.

Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Nature Communications (2024)

First author/s: Raymant M et al.
Corresponding author/s: Schmid M

Next Directions in the Neuroscience of Cancers Arising outside the CNS

Cancer Discovery (2024)

First author/s: Amit M et al.
Corresponding author/s: Borniger J

Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes

Neuro-Oncology (2024)

First author/s: Dankner M, Maritan S et al.
Corresponding author/s: Siegel P

2023. Brain Metastasis Group publications 

Updating cancer research with patient-focused networks

Trends in Cancer (2023)

First author/s: Valiente M, Ortega-Paino E
Corresponding author/s: Valiente M

Growth exponents reflect evolutionary processes and treatment response in brain metastases

npj Systems Biology and Applications (2023)

First author/s: Ocaña-Tienda B et al.
Corresponding author/s: Ocaña-Tienda B

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits

Cancer Cell (2023)

First author/s: Sanchez-Aguilera A, Masmudi-Martín M et al.
Corresponding author/s: Menéndez de la Prida L, Valiente M

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

STAR Protocols (2023)

First author/s: Zhu L et al.
Corresponding author/s: Valiente M

Emerging targets for cancer treatment: S100A9/RAGE

ESMO Open (2023)

First author/s: Valiente M
Corresponding author/s: Valiente M, Sepúlveda JM, Pérez A

2022. Brain Metastasis Group publications 

Toward plasmonic neural probes: SERS detection of neurotransmitters through gold nanoislands-decorated tapered optical fibers with sub-10 nm gaps

Advanced Materials (2023)

First author/s: Zheng D et al.
Corresponding author/s: Zheng D, De Vittorio M, and Pisanello F

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

Nature Medicine (2022)

First author/s: Monteiro C, Miarka L et al.
Corresponding author/s: Valiente M

A clinically-compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

EMBO Molecular Medicine (2022)

First author/s: Zhu L et al.
Corresponding author/s: Valiente M

2021. Brain Metastasis Group publications 

Animal models of brain metastasis

Neuro-Oncology Advances (2021)

First author/s: Miarka L
Corresponding author/s: Valiente M

Plasmonics on a neural implant: engineering light–matter interactions on the nonplanar surface of tapered optical fibers

Advanced Optical Materials (2021)

First author/s: Pisano F et al.
Corresponding author/s: Pisano F, Pisanello F

Brain microenvironment heterogeneity: potential value for brain tumors

Frontiers in Oncology (2021)

First author/s: Álvaro-Espinosa L et al.
Corresponding author/s: Priego N

Challenges and novel opportunities of radiation therapy for brain metastases in non-small cell lung cancer

Cancers (2021)

First author/s: Jablonska PA, Bosch-Barrera J et al.
Corresponding author/s: Calvo A, Aristu J

Organotypic brain cultures for metastasis research

Neuromethods (2021)

First author/s: Zhu L
Corresponding author/s: Valiente M

Brain metastasis models: what do we need to aim for better treatments.

Adv. Drug Deliv. Rev. (2021)

First author/s: Masmudi-Martín M, Zhu L et al.
Corresponding author/s: Valiente M

2020. Brain Metastasis Group publications 

Vascular co-option in brain metastasis

Angiogenesis (2020)

First author/s: García-Gómez P
Corresponding author/s: Valiente M

Brain metastases cell partners and tumor microenvironment

Central Nervous System Metastases (2020)

First author/s: García-Gómez P et al.
Corresponding author/s: Valiente M

Universal scaling laws rule explosive growth in human cancers

Nature Physics (2020)

First author/s: Pérez-García VM et al.
Corresponding author/s: Pérez-García VM

Vascular co-option

Tumor vascularization (2020)

First author/s: García-Gómez P
Corresponding author/s: Valiente M

An inbred ecosystem that supports medulloblastoma

Immunity (2020)

First author/s: De Pablos-Aragoneses A
Corresponding author/s: Valiente M

Preclinical models of brain metastasis

Central Nervous System Metastases: Diagnosis and Treatment (2020)

First author/s: Zhu L
Corresponding author/s: Valiente M

Immunotherapy in NSCLC patients with brain metastases. Understanding brain tumor microenvironment and dissecting outcomes from immune checkpoint blockade in the clinic

Cancer Treatment Reviews (2020)

First author/s: Vilariño N et al.
Corresponding author/s: Nadal E

Brain Metastasis Cell Lines Panel: a public resource for organotropic cell lines

Cancer Research (2020)

First author/s: Valiente M et al.
Corresponding author/s: Valiente M

Breaking down the wall: the strategic plan of cancer to conquer the brain.

Epilepsy Currents (2020)

First author/s: Valiente M, de la Prida L
Corresponding author/s: Valiente M, de la Prida L

2019. Brain Metastasis Group publications 

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis

Cell Reports (2019)

First author/s: Wingrove E et al.
Corresponding author/s: Nguyen D

The Potential of Astrocytes as Immune Modulators in Brain Tumors

Frontiers in Immunology (2019)

First author/s: Priego N
Corresponding author/s: Valiente M

2018. Brain Metastasis Group publications 

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression

Acta Neuropathol (2018)

First author/s: Mustafa DAM et al.
Corresponding author/s: Kros JM

Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion

ESMO Open (2018)

First author/s: Preusser M et al.
Corresponding author/s: Preusser M

The evolving landscape of brain metastasis

Trends in Cancer (2018)

First author/s: Valiente M et al.
Corresponding author/s: Valiente M, Soffietti R

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

Nature Cell Biology (2018)

First author/s: Er E et al.
Corresponding author/s: Massagué J

Silibinin is a direct inhibitor of STAT3

Food Chem Toxicol (2018)

First author/s: Verdura S et al.
Corresponding author/s: Bosch-Barrera J

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Nature Medicine (2018)

First author/s: Priego N et al.
Corresponding author/s: Valiente M

2017. Brain Metastasis Group publications 

Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons

Cell Reports (2017)

First author/s: Bartolini G et al.
Corresponding author/s: Marín O

Reactive Astrocytes in Brain Metastasis

Frontiers in Oncology (2017)

First author/s: Wasilewsky D et al.
Corresponding author/s: Valiente M

2014-2009. Brain Metastasis Group publications 

Migration of cortical interneurons relies on branched leading processes dynamics

Cell Adhesion & Migration (2009)

First author/s: Valiente M, Martini FJ
Corresponding author/s: Valiente M, Martini FJ

Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration

Development (2009)

First author/s: Martini FJ, Valiente M et al.
Corresponding author/s: Valdeolmillos M, Marín O

Control of cortical GABA circuitry development by Nrg1 and ErbB4

Nature (2010)

First author/s: Fazzari P et al.
Corresponding author/s: Marín O

Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

J. Comp. Neurol. (2010)

First author/s: Martín-Ibáñez R et al.
Corresponding author/s: Canals JM

Guiding Neuronal Cell Migrations

Cold Spring Harb. Perspect. Biol. (2010)

First author/s: Marín O et al.
Corresponding author/s: Marín O

Neuronal migration mechanisms in development and disease

Curr. Opin. Neurobiol. (2010)

First author/s: Valiente M
Corresponding author/s: Marín O

Focal Adhesion Kinase modulates radial glia-dependent neuronal migration through Connexin-26

J Neurosci (2011)

First author/s: Valiente M et al.
Corresponding author/s: Marín O

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

Cell (2014)

First author/s: Valiente M et al.
Corresponding author/s: Massagué J

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

eLife (2014)

First author/s: Vanharanta S et al.
Corresponding author/s: Massagué J

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