Welcome to
Valiente Lab
Brain Metastasis Group

The laboratory develops research
projects on brain metastases.

What do we do?

Our objective is to understand the biology of brain metastasis in experimental models in order to develop new opportunities for treating patients suffering from this disease.

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Projects

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Drug discovery
METPlatform
Are there more effective ways to find drugs working against brain metastasis?
Resistance
Radiation
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Resistance
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?

Our
Team

Meet the team

We apply a multidisciplinary approach to study the biology of brain metastasis as a strategy to create new opportunities to improve the clinical management of the disease. Our team consists of technicians, graduate students and postdoctoral researchers with experience in different scientific fields.

Last
Publications

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TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.

Cancer Discovery (2024)

First author/s: Priego N et al.
Corresponding author/s: Valiente M

RET overexpression leads to increased brain metastatic competency in luminal breast cancer

JNCI: Journal of the National Cancer Institute (2024)

First Author/s: Jagust P et al.
Corresponding author/s:Young L.

Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Nature Communications (2024)

First author/s: Raymant M et al.
Corresponding author/s: Schmid M

Next Directions in the Neuroscience of Cancers Arising outside the CNS

Cancer Discovery (2024)

First author/s: Amit M et al.
Corresponding author/s: Borniger J

Viewpoint: Brain Metastasis

Nat Rev Cancer (2020)

First author/s: Boire A, Brastianos P, Garzia L, Valiente M
Corresponding author/s: Boire A, Brastianos P, Garzia L, Valiente M

Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes

Neuro-Oncology (2024)

First author/s: Dankner M, Maritan S et al.
Corresponding author/s: Siegel P

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Valiente Lab
CNIO - Centro Nacional de Investigaciones Oncológicas C/ Melchor Fernández Almagro, 3 · E-28029 Madrid

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