Related projects 


Link to publications


Toward plasmonic neural probes: SERS detection of neurotransmitters through gold nanoislands-decorated tapered optical fibers with sub-10 nm gaps.

Zheng D, Pisano F, Collard L, Balena A, Pisanello M, Spagnolo B, Mach-Batlle R, Tantussi F, Carbone L, De Angelis F, Valiente M, de La Prida L, Ciracì C, De Vittorio M, Pisanello F.

Advanced Materials (2022).

Link to publication


Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente. STAR Protocols (2023)

Link to publication

Our lab together with our collaborators, which include physicists, neuroscientists and engineers, are exploiting the properties of light to design, test and apply the next generation of plasmonic devices to improve the diagnosis and treatment of brain metastasis.

Low-invasive probes are designed to use the light for two purposes:

  1. Modulate the permeability of the blood-brain barrier (BBB)/ blood-tumor barrier (BTB), so we can increase the concentration of anti-tumor drugs in the brain.
  2. Apply Raman technology to characterize the complexity of the tumor itself and the surrounding microenvironment.

Our initial tests suggest that we have created a unique tool that could be exploited according to the two major goals.

NANOBRIGHT could establish a better scenario for diagnosing and treating brain tumors by avoiding highly invasive methodologies as well as increase the armamentarium to challenge both primary and secondary tumors in the brain.

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