Welcome to
Valiente Lab
Brain Metastasis Group

The laboratory develops research
projects on brain metastases.

What do we do?

Our objective is to understand the biology of brain metastasis in experimental models in order to develop new opportunities for treating patients suffering from this disease.

Projects

Drug discovery
METPlatform
Are there more effective ways to find drugs working against brain metastasis?
Resistance
Radiation
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Resistance
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?

Our
Team

We apply a multidisciplinary approach to study the biology of brain metastasis as a strategy to create new opportunities to improve the clinical management of the disease. Our team consists of technicians, graduate students and postdoctoral researchers with experience in different scientific fields.

Last
Publications

2023

Updating cancer research with patient-focused networks

Manuel Valiente

Trends in Cancer

2023

Growth exponents reflect evolutionary processes and treatment response in brain metastases.

Ocaña-Tienda B, Pérez-Beteta J, Jiménez-Sánchez J, Molina-García D, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta L, Valiente M, Zhu L, García-Gómez P, González-Del Portillo E, Llorente M, Carballo N, Arana E, Pérez-García V.

npj system biology and applications

2023

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits.

Sanchez-Aguilera A**, Masmudi-Martín M**, Navas-Olive A, Baena P, Hernández-Oliver C, Priego N, Cordón-Barris L, Alvaro-Espinosa L, García S, Martínez S, Lafarga M, RENACER, Lin MZ, Al-Shahrour F, Menendez de la Prida L* and Valiente M*.

Cancer Cell

2023

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente

STAR Protocols

2023

Emerging targets for cancer treatment: S100A9/RAGE

M. Valiente, J.M. Sepúlveda, A. Pérez

ESMO Open

2022

Toward plasmonic neural probes: SERS detection of neurotransmitters through gold nanoislands-decorated tapered optical fibers with sub-10 nm gaps

Zheng D, Pisano F, Collard L, Balena A, Pisanello M, Spagnolo B, Mach-Batlle R, Tantussi F, Carbone L, De Angelis F, Valiente M, de La Prida L, Ciracì C, De Vittorio M, Pisanello F.

Advanced Materials

Patients & Families

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Society

Interviews

Talks

Round tables

Laboratory results and scientific projects

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Funded by: