Welcome to
Valiente Lab
Brain Metastasis Group

The laboratory develops research
projects on brain metastases.

What do we do?

Our objective is to understand the biology of brain metastasis in experimental models in order to develop new opportunities for treating patients suffering from this disease.


Drug discovery
Are there more effective ways to find drugs working against brain metastasis?
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?


We apply a multidisciplinary approach to study the biology of brain metastasis as a strategy to create new opportunities to improve the clinical management of the disease. Our team consists of technicians, graduate students and postdoctoral researchers with experience in different scientific fields.


Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Nature Communications (2024)

First author/s: Raymant M et al.
Corresponding author/s: Schmid M

Next Directions in the Neuroscience of Cancers Arising outside the CNS

Cancer Discovery (2024)

First author/s: Amit M et al.
Corresponding author/s: Borniger J

Viewpoint: Brain Metastasis

Nat Rev Cancer (2020)

First author/s: Boire A, Brastianos P, Garzia L, Valiente M
Corresponding author/s: Boire A, Brastianos P, Garzia L, Valiente M

Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes

Neuro-Oncology (2024)

First author/s: Dankner M, Maritan S et al.
Corresponding author/s: Siegel P

Updating cancer research with patient-focused networks

Trends in Cancer (2023)

First author/s: Valiente M, Ortega-Paino E
Corresponding author/s: Valiente M

Growth exponents reflect evolutionary processes and treatment response in brain metastases

npj Systems Biology and Applications (2023)

First author/s: Ocaña-Tienda B et al.
Corresponding author/s: Ocaña-Tienda B

Patients & Families





Round tables

Laboratory results and scientific projects


Funded by: