Welcome to
Valiente Lab
Brain Metastasis Group

The laboratory develops research
projects on brain metastases.

What do we do?

Our objective is to understand the biology of brain metastasis in experimental models in order to develop new opportunities for treating patients suffering from this disease.

Projects

Drug discovery
METPlatform
Are there more effective ways to find drugs working against brain metastasis?
Resistance
Radiation
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Resistance
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?

Our
Team

We apply a multidisciplinary approach to study the biology of brain metastasis as a strategy to create new opportunities to improve the clinical management of the disease. Our team consists of technicians, graduate students and postdoctoral researchers with experience in different scientific fields.

Last
Publications

2022

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. 

Monteiro C, Miarka L, et al.

Nature Medicine

2022

A clinically-compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.

Zhu L, et al.

EMBO Mol. Med.

2021

Plasmonics on a neural implant: engineering light–matter interactions on the nonplanar surface of tapered optical fibers. 

Pisano F, et al.

Adv.Opt. Mater.

2021

Animal models of brain metastasis. 

Miarka L and Valiente M

Neuro-Oncol Adv.

2021

Challenges and novel opportunities of radiation therapy for brain metastases in non-small cell lung cancer.

Jablonska PA et al.

Cancers

2021

Brain metastasis models: what do we need to aim for better treatments.

Masmudi-Martín M, Zhu L et al.

Advanced Drug Delivery Reviews.

Patients & Families

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Society

Interviews

Talks

Round tables

Laboratory results and scientific projects

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Funded by: