Our publications reflect our interests in the fields of Cancer Biology and Neuroscience. This allows us to study brain metastases using a variety of techniques. Here are our most significant contributions to both disciplines.

2023. Brain Metastasis Group publications 

Updating cancer research with patient-focused networks

Manuel Valiente & Eva Ortega-Paíno

Trends in Cancer

Growth exponents reflect evolutionary processes and treatment response in brain metastases.

Ocaña-Tienda B, Pérez-Beteta J, Jiménez-Sánchez J, Molina-García D, Ortiz de Mendivil A, Asenjo B, Albillo D, Pérez-Romasanta L, Valiente M, Zhu L, García-Gómez P, González-Del Portillo E, Llorente M, Carballo N, Arana E, Pérez-García V.

npj system biology and applications

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits.

Sanchez-Aguilera A**, Masmudi-Martín M**, Navas-Olive A, Baena P, Hernández-Oliver C, Priego N, Cordón-Barris L, Alvaro-Espinosa L, García S, Martínez S, Lafarga M, RENACER, Lin MZ, Al-Shahrour F, Menendez de la Prida L* and Valiente M*.

Cancer Cell

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente

STAR Protocols

Emerging targets for cancer treatment: S100A9/RAGE

M. Valiente, J.M. Sepúlveda, A. Pérez


2022. Brain Metastasis Group publications 

Toward plasmonic neural probes: SERS detection of neurotransmitters through gold nanoislands-decorated tapered optical fibers with sub-10 nm gaps

Zheng D, Pisano F, Collard L, Balena A, Pisanello M, Spagnolo B, Mach-Batlle R, Tantussi F, Carbone L, De Angelis F, Valiente M, de La Prida L, Ciracì C, De Vittorio M, Pisanello F.

Advanced Materials

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. 

Monteiro C, Miarka L, et al.

Nature Medicine

A clinically-compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.

Zhu L, et al.

EMBO Mol. Med.

2021. Brain Metastasis Group publications 

Animal models of brain metastasis. 

Miarka L and Valiente M

Neuro-Oncol Adv.

Plasmonics on a neural implant: engineering light–matter interactions on the nonplanar surface of tapered optical fibers. 

Pisano F, et al.

Adv.Opt. Mater.

Brain microenvironment heterogeneity: potential value for brain tumors

Álvaro-Espinosa L, de Pablos-Aragoneses A, et al.

Front. Oncol

Challenges and novel opportunities of radiation therapy for brain metastases in non-small cell lung cancer.

Jablonska PA et al.


Brain metastasis models: what do we need to aim for better treatments.

Masmudi-Martín M, Zhu L et al.

Advanced Drug Delivery Reviews.

2020. Brain Metastasis Group publications 

Brain metastases cell partners and tumor microenvironment

García-Gómez, Priego, Álvaro-Espinosa, Valiente M.


Universal scaling laws rule explosive growth in human cancers

Pérez-García VM et al.

Nature Physics

Vascular co-option

García-Gómez P and Valiente M

Tumor vascularization. Elsevier

An inbred ecosystem that supports medulloblastoma

Pablos-Aragoneses A and Valiente M


Preclinical models of brain metastasis

Zhu L and Valiente M

Central Nervous System Metastases: Diagnosis and Treatment. Springer

Organotypic brain cultures for metastasis research

Zhu L and Valiente M


Immunotherapy in NSCLC patients with brain metastases. Understanding brain tumor microenvironment and dissecting outcomes from immune checkpoint blockade in the clinic

Vilariño N et al.

Cancer Treatment Reviews. (2020)

Brain Metastasis Cell Lines Panel: a public resource for organotropic cell lines

Valiente M et al.

Cancer Research

Breaking down the wall: the strategic plan of cancer to conquer the brain.

Valiente M and de la Prida.

Epilepsy Currents. (2020).

2019. Brain Metastasis Group publications 

Vascular co-option in brain metastasis

García-Gómez and Valiente


Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis

Wingrove et al.

Cell Reports

The Potential of Astrocytes as Immune Modulators in Brain Tumors

Priego and Valiente

Front. Immunol

Brain metastasis

Boire, Brastianos, Garzia and Valiente

Nat Rev Cancer

2018. Brain Metastasis Group publications 

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression

Mustafa et al.

Acta Neuropathol

Recent advances in the biology and treatment of brain metastases of non- small cell lung cancer: summary of a multidisciplinary roundtable discussion

Preusser et al.


The evolving landscape of brain metastasis

Valiente et al

Trends in Cancer

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

Er et al

Nat Cell Biol

Silibinin is a direct inhibitor of STAT3

Verdura et al.

Food Chem Toxicol

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Priego et al.

Nat Med

2017. Brain Metastasis Group publications 

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

Chen et al.


Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons

Bartolini et al.

Cell Reports

Reactive Astrocytes in Brain Metastasis

Wasilewski et al.

Front Oncol

2014-2009. Brain Metastasis Group publications 

Migration of cortical interneurons relies on branched leading processes dynamics

Valiente and Martini

Cell Adhesion & Migration

Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration

Martini, Valiente et al.


Control of cortical GABA circuitry development by Nrg1 and ErbB4

Fazzari et al.


Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

Martín-Ibáñez et al.

J Comp Neurol

Guiding Neuronal Cell Migrations

Marín et al.

Cold Spring Harb Perspect Biol

Neuronal migration mechanisms in development and disease

Valiente and Marín

Curr Opin Neurobiol

Focal Adhesion Kinase modulates radial glia-dependent neuronal migration through Connexin-26

Valiente et al.

J Neurosci

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

Valiente et al.


Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

Vanharanta et al.