Welcome to
Valiente Lab
Brain Metastasis Group

The laboratory develops research
projects on brain metastases.

What do we do?

Our objective is to understand the biology of brain metastasis in experimental models in order to develop new opportunities for treating patients suffering from this disease.

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Projects

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Drug discovery
METPlatform
Are there more effective ways to find drugs working against brain metastasis?
Resistance
Radiation
Radiation gets immediate access to the brain but it is not as effective as expected, why?
Resistance
Local relapse
Surgery is a key aspect in the treatment of some patients with brain metastasis. If the metastasis is removed, why is this therapy not curative?

Our
Team

Meet the team

We apply a multidisciplinary approach to study the biology of brain metastasis as a strategy to create new opportunities to improve the clinical management of the disease. Our team consists of technicians, graduate students and postdoctoral researchers with experience in different scientific fields.

Last
Publications

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Next Directions in the Neuroscience of Cancers Arising outside the CNS

Cancer Discovery (2024)

First author/s: Amit M et al.
Corresponding author/s: Borniger J

Viewpoint: Brain Metastasis

Nat Rev Cancer (2020)

First author/s: Boire A, Brastianos P, Garzia L, Valiente M
Corresponding author/s: Boire A, Brastianos P, Garzia L, Valiente M

Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes

Neuro-Oncology (2024)

First author/s: Dankner M, Maritan S et al.
Corresponding author/s: Siegel P

Updating cancer research with patient-focused networks

Trends in Cancer (2023)

First author/s: Valiente M, Ortega-Paino E
Corresponding author/s: Valiente M

Growth exponents reflect evolutionary processes and treatment response in brain metastases

npj Systems Biology and Applications (2023)

First author/s: Ocaña-Tienda B et al.
Corresponding author/s: Ocaña-Tienda B

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits

Cancer Cell (2023)

First author/s: Sanchez-Aguilera A, Masmudi-Martín M et al.
Corresponding author/s: Menéndez de la Prida L, Valiente M

Patients & Families

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Society

Interviews

Talks

Round tables

Laboratory results and scientific projects

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Valiente Lab
CNIO - Centro Nacional de Investigaciones Oncológicas C/ Melchor Fernández Almagro, 3 · E-28029 Madrid

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